Saturday, 23 January 2016

5 4 3 2 1... MIGRAINE

Neat trick to remember the features of migraine: (5, 4, 3, 2, 1)

  • >5 attacks a day
  • lasting 4 hours to 3 days
  • 2 or more features: Unilateral, Pulsating, Moderate/severe intensity, Aggravated or causing avoidance of routine physical activity
  • 1 of either Nausea and vomiting or sensitivity to light (photophobia) and sound (phonophobia)

The precise diagnostic criteria can be found here for details: International Headache Society

Treatment: 

  • Avoid and control triggers; e.g. foods containing tyramine (cheese, chocolate, wine), 
  • Mild-moderate: paracetomol, NSAIDS
  • Moderate-severe: Triptans (NO OPIATES!)
  • Refractory: try combinations Triptans + NSAIDS
  • Prophylaxis if more than 3 episodes a month, if it interferes with daily life or acute treatment is ineffective: AEDs, BBs, CCBs, Triptans, 
Some migraines have a characteristic 'Aura' before. Typically visual symptoms, a brilliant scintillating scotoma, lasting between 5-60 minutes

There are also many different types of Migraine, some worth noting;

Basilar type Migraine: accompanying brainstem symptoms e.g. dysarthria, vertigo, diplopia, ataxia. 


Familial hemiplegic Migraine: aura of fully reversible motor weakness, aura lasts unusually long 5 mins to 24 hours, pt has at least one affected relative.

Chronic Migraine: Migraine for greater than 15 days a month, for at least three months. Basically a migraine every other day, very disturbing.

WTF if a Triptan?
5-HT1B/1D receptor agonist, causes constriction of cranial blood vessels and inhibits production of inflammatory neuropeptides. Side effects include: Serotonin syndrome and coronary spasm. also used to altitude sickness.


#Migraine #Neurology #FOAMed #MedED

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